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Anthrogen

Anthrogen

Job listing

San Francisco, USAUp to $500K + Equity

Head of Technical Staff at Anthrogen - YC-backed biotech startup

Anthrogen is hiring a Head of Technical Staff in San Francisco to lead the production of the world’s largest protein foundation models. Backed by Y Combinator and Paul Graham with $11M in funding, Anthrogen is training 102B parameter models to design novel therapeutics and molecular machines. If you have 2+ years of experience at a frontier AI lab like OpenAI or DeepMind and want to apply large-scale ML to biological discovery, this role offers a $500K base salary and the chance to lead a category-defining biotech startup’s technical trajectory.

Overview

Role overview

Lead the end-to-end production pipeline for the world’s largest protein foundation models. You will oversee pretraining, post-training, and inference for Odyssey, a 102B parameter biological model. This hands-on leadership role bridges frontier AI research and wet-lab validation to create novel therapeutics and molecular machines that do not exist in nature.

Company

Anthrogen

Anthrogen

Biotechnology

Anthrogen.com - YC S24 biotech startup designing novel proteins

Responsibilities

What you will do

  • Own the production model pipeline including large-scale pretraining, post-training, and inference optimization for flagship protein models.
  • Lead and scale the Technical Staff team while collaborating directly with the co-founders on architectural decisions and research direction.
  • Interface between fundamental AI research and the wet-lab platform team to validate generative designs through massively parallelized experiments.

Candidate profile

Who this is a fit for

  • Must have 2+ years of experience at a frontier lab such as OpenAI, Anthropic, DeepMind, or top bio-AI labs like Isomorphic or Baker Lab.
  • Proven track record of high-caliber research with publications at top venues like NeurIPS, ICML, or ICLR and hands-on large-scale training experience.
  • Deep technical expertise in ML/AI architectures with a genuine passion for biology; a PhD is welcomed but caliber and work history are prioritized.

What makes it remarkable

Why this role is remarkable

  • Work on Odyssey, the largest reported biological foundation model with 102B parameters, scaling AI to design proteins with atomic precision.
  • Join a high-intensity YC S24 team backed by $11M from Paul Graham, Box Group, and other top-tier investors as they prepare for Series A.
  • Unique opportunity to move beyond digital-only AI into physical-world impact where your models design molecules that become real-world catalysts and medicines.

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