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Primamente

Primamente

Job listing

San Francisco, United StatesNot Disclosed

Machine Learning Research Engineer at Prima Mente - Frontier Biology AI Lab

Join Prima Mente, a frontier biology AI lab, to build foundation models that decode the human brain. We are training 7B+ parameter models on 1.9T tokens using 256 H200 GPUs to detect neurological diseases years before symptoms appear. As an ML Research Engineer, you will own model architecture and low-level optimizations, bridging the gap between cutting-edge research and clinical impact. If you want to apply large-scale ML systems to the most complex challenge in biology while working alongside world-class researchers in SF or London, this is your opportunity to change the future of human health.

Overview

Role overview

You will design and scale biological foundation models to decode the human brain. Training 7B+ parameter models on trillions of tokens, you will bridge high-level research and production-grade systems. This role is central to developing AI that detects neurological diseases years earlier, directly translating frontier machine learning into life-changing clinical outcomes.

Company

Primamente

Primamente

Healthcare

Prima Mente - Frontier Biology AI Lab

Responsibilities

What you will do

  • Implement high-performance ML algorithms and distributed training infrastructure optimized for massive-scale multi-omic datasets.
  • Design and develop robust experimentation pipelines to enable rapid iteration, precise evaluations, and reproducible research outcomes.
  • Refactor research prototypes into clean, maintainable, and performant production-grade repositories suitable for large-scale deployments.

Candidate profile

Who this is a fit for

  • Extensive experience training and deploying large-scale models (7B+ parameters) with deep expertise in PyTorch, JAX, or TensorFlow.
  • Strong background in low-level optimization including quantization, CUDA/Triton, and hardware-specific tuning for GPU/TPU/HPU clusters.
  • Proven track record of handling massive datasets (2T+ tokens) and building scalable data processing workflows for high-throughput training.

What makes it remarkable

Why this role is remarkable

  • Work at the absolute frontier of AI and biology, training 7B+ parameter models on 1.9T tokens of epigenomic data using a cluster of 256 H200 GPUs.
  • Direct ownership of research direction and model architecture decisions in a flat organization where technical excellence profoundly shapes the company’s trajectory.
  • Join a mission-critical lab solving the world's most complex biological system—the brain—to protect against Alzheimer's and other neurological diseases.

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