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Wet Lab Scientist/Enzyme Engineer at Ligo Biosciences

Are you ready to redefine the limits of synthetic biology? We are looking for a talented Wet Lab Scientist or Enzyme Engineer to join a San Francisco startup building the next generation of high-throughput DNA-writing technology. You will lead the development of critical enzymatic assays and protein engineering workflows that power our core platform. If you thrive in a fast-paced lab environment and want to solve the most pressing challenges in DNA synthesis, this is the role for you. Join a team of world-class scientists and engineers in the heart of the biotech ecosystem.

Overview

Role overview

We are looking for a Wet Lab Scientist or Enzyme Engineer to join our core technical team. You will lead the development and optimization of novel enzymatic assays, directly impacting our high-throughput DNA-writing platform. This is a critical role for an experimentalist who thrives at the intersection of molecular biology and protein engineering.

Company

Ligo Biosciences

Ligo Biosciences

San Francisco-based biotech startup developing high-throughput DNA-writing technology to revolutionize synthetic biology and drug discovery

Responsibilities

What you will do

  • Design, execute, and troubleshoot complex wet lab experiments and enzymatic assays to improve DNA synthesis efficiency.
  • Iterate on protein engineering strategies and screen enzyme variants to optimize performance within our proprietary platform.
  • Analyze large datasets from high-throughput screens to inform future experimental design and platform development.

Candidate profile

Who this is a fit for

  • Holds an advanced degree (PhD or equivalent experience) in Molecular Biology, Biochemistry, Bioengineering, or a related field.
  • Possesses deep technical expertise in wet lab operations, specifically regarding protein characterization, enzyme kinetics, or assay development.
  • Demonstrates a proactive, startup-ready mindset with the ability to move fast and pivot based on experimental results.

What makes it remarkable

Why this role is remarkable

  • Join a mission-driven team solving the fundamental bottleneck in synthetic biology: the speed and scale of DNA synthesis.
  • Work in an high-energy, on-site lab environment in San Francisco with access to cutting-edge instrumentation and a collaborative team of experts.
  • Play a founding-level role in establishing the wet lab protocols and enzyme engineering pipelines that will scale the company’s core technology.

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